Hericium erinaceus: the mushroom that improves mood and sleep in overweight patients

Article author: Ilaria Redaelli Article published at: Aug 7, 2025
Hericium erinaceus: il fungo che migliora umore e sonno nei pazienti in sovrappeso

🌿 Introduction

Hericium erinaceus, also known as "Lion's Mane," is a medicinal mushroom known for its neuroprotective properties. A recent study published in Evidence-Based Complementary and Alternative Medicine explored its impact on mood and sleep quality in overweight or obese patients.


🧪 The study in brief: how it was conducted

The study was conducted at the Obesity Center of the Luigi Devoto Occupational Health Clinic , part of the IRCCS Fondazione Policlinico di Milano . It involved 77 overweight or obese adult volunteers with mood or sleep disorders or compulsive eating .

📍 Where: Milan, Italy
🗓️ When: Study completed in 2019, with supplementation for 8 weeks
💊 How: Each participant took Hericium erinaceus extract orally , while also following a controlled low-calorie diet.

Before and after administration, the researchers monitored:

  • Symptoms of anxiety, depression and insomnia through questionnaires

  • Blood levels of BDNF (brain-derived neurotrophic factor) and pro-BDNF , biomarkers linked to mental health

🔍 The results?

After 8 weeks, a significant reduction in anxiety and depressive symptoms , improved sleep , and increased pro-BDNF levels were observed , suggesting potential neuronal regeneration.

👉 Read the full study on PubMed Central



🧪 Mechanisms of action

🧠 BDNF stimulation

Hericium erinaceus appears to influence levels of BDNF (Brain-Derived Neurotrophic Factor), a protein involved in neuronal plasticity and mood regulation. Increased BDNF is associated with improvements in depression and anxiety.

😴 Improved sleep

Study participants reported improved sleep quality, with reduced insomnia and deeper, more restful sleep.


💡 Practical implications

This study suggests that Hericium erinaceus may be a valuable supplement for improving mood and sleep quality, especially in overweight or obese individuals. Its effect on BDNF and its ability to improve sleep make it a promising nutraceutical supplement.


🍄 Try JUN's Hericium

At JUN, we believe in the power of nature, backed by science. We offer high-quality Hericium erinaceus extract capsules, ideal for supporting mental well-being and improving sleep quality.

👉 Find out more about junlei.it


Note: This article is based on the study “Hericium erinaceus Improves Mood and Sleep Disorders in Patients Affected by Overweight or Obesity: Could Circulating Pro-BDNF and BDNF Be Potential Biomarkers?” published in Evidence-Based Complementary and Alternative Medicine .

Article author: Ilaria Redaelli Article published at: Aug 7, 2025